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Polychlorinated biphenyl (Aroclor 1254) induced changes in femur morphometry calcium metabolism and nephrotoxicity

Technical Report ·
OSTI ID:6967753

Experiments were performed to investigate the effects of polychlorinated biphenyl (PCB) on calcium metabolism, femur morphometry, and nephrotoxicity. Fischer 344 rats were dosed daily IG for 5, 10, or 15 weeks with 0, 0.1, 1, 10 or 25 mg PCB/kg body weight. After 5, 10 and 15 weeks, liver weight and liver-to-body weight ratio were increased at the two higher dose levels. Overt toxicity was observed at the highest dose level after 10 and 15 weeks as evidenced by significantly smaller body weight. Urinary alkaline phosphatase and lactate dehydrogenase activities were elevated at 5, 10 and 15 weeks of PCB exposure and the kidney-to-body weight ratios were elevated at the 10 and 25 mg/kg dose levels after 10 and 15 weeks of exposure indicating nephrotoxicity. Hypercalcemia was present at the highest dose level after 5 and 10 weeks of exposure but serum calcium concentration was normal at 15 weeks. Serum triglycerides were significantly elevated after 5 weeks of exposure but were significantly decreased after 10 and 15 weeks of PCB exposure. Serum cholesterol was significantly elevated at the two higher dose levels at all three periods. The results demonstrate that PCB exposure effects calcium metabolism and bone morphometry and is nephrotoxic.

Research Organization:
Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
OSTI ID:
6967753
Report Number(s):
PB-90-146085/XAB; EPA--600/J-89/222
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ALKALINE PHOSPHATASE
ANIMALS
AROMATICS
BLOOD SERUM
BODY
CALCIUM
CHLORINATED AROMATIC HYDROCARBONS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENZYMES
ESTERASES
FEMUR
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HEMIACETAL DEHYDROGENASES
HYDROLASES
KIDNEYS
LACTATE DEHYDROGENASE
LIVER
MAMMALS
METABOLISM
METALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHOSPHATASES
RATS
RODENTS
SENSITIVITY
SKELETON
TOXICITY
VERTEBRATES