In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas

Journal Article · Thu Dec 01 04:00:00 EST 1983 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410140604· OSTI ID:6964443

Rhodes, C G; Wise, R J; Gibbs, J M; Frackowiak, R S; Hatazawa, J; Palmer, A J; Thomas, D G; Jones, T

Abnormalities in the oxidative metabolism of glucose in human cerebral gliomas have been studied in seven patients using positron emission tomography. Measurements of regional cerebral blood flow and oxygen consumption were obtained using the oxygen-15 steady-state inhalation technique. Values of regional cerebral glucose consumption were obtained using fluorine 18-labeled 2-fluoro-2-deoxy-D-glucose and a simplification of the method of Sokoloff. Functional values were obtained for regions of tumor and brain tissue in the middle cerebral artery territory of the contralateral cortex. Values of regional glucose consumption were calculated for both regions using a value of the lumped constant quoted for normal brain tissue (0.42). Tumor regional cerebral blood flow was comparable to that in the contralateral cortex, whereas regional cerebral oxygen consumption was depressed. This depression resulted in low tumor values of the fractional oxygen extraction ratio (0.21 +/- 0.07), indicating that oxygen supply exceeded the metabolic demand. In contrast, tumor regional cerebral glucose consumption was not depressed and regional glucose extraction ratios were similar for tumor and brain tissue. The metabolic uncoupling between regional oxygen consumption and regional glucose consumption (CMRO2/CMRGlu . 0.24 +/- 0.07 ml of oxygen per milligram of glucose) is indicative of increased aerobic glycolysis.

• Research Organization: MRC Cyclotron Unit, Hammersmith Hospital, London, England
• OSTI ID: 6964443
• Journal Information: Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 14:6; ISSN ANNED
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CONSUMPTION RATES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
GLIOMAS
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEASURING METHODS
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NEOPLASMS
NERVOUS SYSTEM
NONMETALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN
OXYGEN 15
OXYGEN ISOTOPES
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES