Effect of inorganic lead and/or a polychlorinated biphenyl on the developing immune system of mice

Journal Article · · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398309530431· OSTI ID:6962598

Talcott, P A; Koller, L D

Approximately 200 female Swiss-Webster mice, six to eight weeks of age, were divided into eight groups. Three of these groups were fed 10, 100, or 250 ppm Aroclor 1254. One group was treated with 1000 ppm lead. Three groups were exposed simultaneously to lead and Aroclor 1254 at concentrations of 10 ppm PCB + 1000 ppm Pb, 100 ppm PCB + 1000 ppm Pb, and 250 ppm PCB + 1000 ppm Pb. Control mice received deionized water and rat food only. All groups were exposed for a period of 12 wk, then bred, with exposure continued throughout gestation and lactation. Offspring were weaned onto the control diet at 3 wk of age. Results from this study indicate a varied effect of lead and/or PCBs on body and organ weights of both dams and their pups, no noticeable detrimental effect on reproduction, and very little effect on the pups' ability to mount an immune response upon challenge with foreign antigens.

• Research Organization: Univ. of Idaho, Moscow
• OSTI ID: 6962598
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 12:2-3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
CHLORINATED AROMATIC HYDROCARBONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
HALOGENATED AROMATIC HYDROCARBONS
IMMUNE REACTIONS
LEAD
MAMMALS
METALS
MICE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
REPRODUCTION
RODENTS
VARIATIONS
VERTEBRATES
WEIGHT