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Circadian rhythms in the urinary excretion of metals and organic substances in healthy men

Journal Article · · Arch. Environ. Health; (United States)
; ; ; ; ; ;
Circadian rhythms in the urinary excretion of metals and organic substances were examined in ten healthy men under conditions of water loading and restriction. Four characteristic rhythms were observed: 1) decreased excretion during the night for lead and urinary flow rate; 2) decreased excretion of hippuric acid, delta-aminolevulinic acid, coproporphyrin, creatinine, and total urinary solutes during the night and morning hours; 3) increased excretion of mercury and zinc during the morning hours; and 4) no significant variation for copper. Excretion of lead, hippuric acid, delta-aminolevulinic acid, and total urinary solutes was significantly correlated with urinary flow rate and creatinine excretion, which suggested that their circadian rhythms were the consequence of reduced glomerular filtration and increased reabsorption by the distal tubule and collecting duct during the night and morning hours. Similarly, it was suggested that the mercury and zinc rhythms resulted partly from increased reabsorption during the night hours; the coproporphyrin rhythm reflected reduced glomerular filtration of coproporphyrinogen during the night and morning hours. 24 references, 4 figures, 1 table.
Research Organization:
Medical Coll. of Oita, Japan
OSTI ID:
6962428
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 38:6; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOLEVULINIC ACID
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
COPPER
DAILY VARIATIONS
ELEMENTS
EXCRETION
FILTRATION
GLOMERULI
HIPPURIC ACID
KIDNEYS
LEAD
MALES
MATERIALS
MERCURY
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
SEPARATION PROCESSES
SOLUTES
TRANSITION ELEMENTS
URINE
VARIATIONS
WASTES
ZINC