The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias
Journal Article
·
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
- Free Univ. of Brussels (Belgium)
- Hopital Saint Louis, Paris (France)
- Weizmann Institute of Science (Israel)
The authors measured the human pim-1 protooncogene (PIM) expression during fetal development and in hematopoietic malignancies. The data indicate that during human fetal hematopoiesis the 33-kDa pim product, p33pim, is highly expressed in the liver and the spleen. In contrast, a the adult stage it is only slightly expressed in circulating granulocytes. Out of 70 hematopoietic malignancies analyzed, 51 patients and 19 cell lines, p33pim was overexpressed in {approx} 30% of the samples, particularly in myeloid and lymphoid acute leukemias. This overexpression was unrelated to any stage of cellular differentiation and was not due to gene rearrangement or amplification. These results imply a physiological role of the pim-1 protooncogene during hematopoietic development and a deregulation in various leukemias.
- OSTI ID:
- 6957911
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 86:22; ISSN 0027-8424; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
AMINO ACIDS
BIOLOGY
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CELL DIFFERENTIATION
CHROMOSOMES
DIGESTIVE SYSTEM
DISEASES
ENZYMES
GENE AMPLIFICATION
GENE REGULATION
GENES
GENETICS
GLANDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HETEROCHROMOSOMES
HYDROXY ACIDS
IMMUNE SYSTEM DISEASES
LEUKEMIA
LIVER
MOLECULAR BIOLOGY
NEOPLASMS
ONCOGENES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
SPLEEN
TRANSFERASES
TYROSINE
59 BASIC BIOLOGICAL SCIENCES
AGE DEPENDENCE
AMINO ACIDS
BIOLOGY
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CELL DIFFERENTIATION
CHROMOSOMES
DIGESTIVE SYSTEM
DISEASES
ENZYMES
GENE AMPLIFICATION
GENE REGULATION
GENES
GENETICS
GLANDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HETEROCHROMOSOMES
HYDROXY ACIDS
IMMUNE SYSTEM DISEASES
LEUKEMIA
LIVER
MOLECULAR BIOLOGY
NEOPLASMS
ONCOGENES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
SPLEEN
TRANSFERASES
TYROSINE