Selection of a model and estimation of principal pharmacokinetic parameters of dioxadet
Journal Article
·
· Pharmaceut. Chem. J.; (United States)
OSTI ID:6956227
The authors study the pharmacokinetics of dioxadet, taking into account all the necessary parameters. Dioxadet-/sup 14/C was used, labeled in the ethyleneimine group, which retains radioactivity after the compound has lost its alkylating properties. The authors synthesized it from 2,2-dimethyl-5-hydroxymethyl-(2,4-dichloro-1,3,5-triazin-6-yl)amino-1,3-dioxane and ethyleneimini-2,3-/sup 14/C, obtained from 1,2-dibromoethane-/sup 14/C. The principal pharmacokinetic parameters of dioxadet for eight rats are shown. The synthesis of dioxadet-/sup 14/C, the radiometry of blood samples, and the calculation of the kinetic curve are all discussed.
- Research Organization:
- N. N. Petrov Scientific-Research Institute of Oncology, Leningrad (USSR)
- OSTI ID:
- 6956227
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 19:10; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
550201 -- Biochemistry-- Tracer Techniques
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTINEOPLASTIC DRUGS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
CARBON 14 COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HETEROCYCLIC COMPOUNDS
IMINES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
RADIOACTIVITY
RATS
REACTION KINETICS
RODENTS
SYNTHESIS
TRACER TECHNIQUES
TRIAZINES
VERTEBRATES
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
550201 -- Biochemistry-- Tracer Techniques
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTINEOPLASTIC DRUGS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
CARBON 14 COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HETEROCYCLIC COMPOUNDS
IMINES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHARMACOLOGY
RADIOACTIVITY
RATS
REACTION KINETICS
RODENTS
SYNTHESIS
TRACER TECHNIQUES
TRIAZINES
VERTEBRATES