Design, synthesis, and biological evaluation of compounds of interest in the chemotherapy of cancer
Thesis/Dissertation
·
OSTI ID:6956214
Part One, entitled, Potential Inhibitors of Inosine Monophosphate (IMP) Dehydrogenase: Synthesis and Stereochemical Assignments for a Class of C-Nucleosides, concerns the synthesis, stereochemical assignments, and biological evaluation of a pair of ..cap alpha.., ..beta..-D-arabinofuranosyl analogues of tiazofurin. The target nucleosides were synthesized from 2,3,5-tri-O-benzyl-1-O-(p-nitrobenzoyl)-D-arabinofuranose. Stereochemical assignments in the series were made on the basis of /sup 1/H and /sup 13/C NMR spectroscopy, two-dimensional (2D FT) NMR, as well as by circular dichroism (CD) spectroscopy. In Part Two, entitled, Substrates of Inhibitors of Enzymes of the Phosphatidylinositol Pathway: Analogues of myo-Inositol, A number of deoxy- and deoxyhalogenocyclitols were synthesized as potential substrates or inhibitors of the primary enzymes of the phosphatidylinositol pathway. Part Three, Synthesis of (2'-/sup 18/O)- and (3'-/sup 18/O)-Adenosine and Ara-A as Well as an Investigation of Their /sup 18/O-Induced /sup 13/C NMR Chemical Shifts, involves the synthesis and characterization of the title compounds.
- Research Organization:
- Alabama Univ., Birmingham (USA). School of Medicine
- OSTI ID:
- 6956214
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600* -- Medicine
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOSINE
ANTINEOPLASTIC DRUGS
BARYONS
CHEMICAL PREPARATION
CHEMICAL SHIFT
CHEMOTHERAPY
DISEASES
DRUGS
ELEMENTARY PARTICLES
ENZYME INHIBITORS
ESTERS
EVEN-EVEN NUCLEI
FERMIONS
HADRONS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LIPIDS
NEOPLASMS
NMR SPECTRA
NUCLEI
NUCLEONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OXYGEN 18
OXYGEN ISOTOPES
PHOSPHOLIPIDS
PROTONS
RIBOSIDES
SPECTRA
STABLE ISOTOPES
STEREOCHEMISTRY
SYNTHESIS
THERAPY
TRACER TECHNIQUES
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOSINE
ANTINEOPLASTIC DRUGS
BARYONS
CHEMICAL PREPARATION
CHEMICAL SHIFT
CHEMOTHERAPY
DISEASES
DRUGS
ELEMENTARY PARTICLES
ENZYME INHIBITORS
ESTERS
EVEN-EVEN NUCLEI
FERMIONS
HADRONS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LIPIDS
NEOPLASMS
NMR SPECTRA
NUCLEI
NUCLEONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OXYGEN 18
OXYGEN ISOTOPES
PHOSPHOLIPIDS
PROTONS
RIBOSIDES
SPECTRA
STABLE ISOTOPES
STEREOCHEMISTRY
SYNTHESIS
THERAPY
TRACER TECHNIQUES