C4BPAL1, a member of the human regulator of complement activation (RCA) gene cluster that resulted from the duplication of the gene coding for the [alpha]-chain of C4b-binding protein
Journal Article
·
· Genomics; (United States)
- Unidad de Immunologia, Madrid (Spain)
The regulator of complement activation (RCA) gene cluster evolved by multiple gene duplications to produce a family of genes coding for proteins that collectively control the activation of the complement system. The authors report here the characterization of C4BPAL1, a member of the human RCA gene cluster that arose from the duplication of the C4BPA gene after the separation of rodent and primate lineages. C4BPAL1 maps 20 kb downstream of the C4BPA gene and is in the same 5[prime] to 3[prime] orientation found for all RCA genes characterized thus far. It includes nine exon-like regions homologous to exons 2-8, 11, and 12 of the C4BPA gene. Analysis of the C4BPAL1 sequence suggests that it is currently a pseudogene in humans. However, comparisons between C4BPAL1 and the human and murine C4BPA genes show sequence conservation, which strongly suggests that, for a long period of time, C4BPAL1 has been a functional gene coding for a protein with structural requirements similar to those of the [alpha]-chain of C4b-binding protein. 50 refs., 5 figs., 1 tab.
- OSTI ID:
- 6955618
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 17:1; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
Similar Records
C4BPAL2: A second duplication of the C4BPA gene in the human RCA gene cluster
Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus
Human genes for the. alpha. and. beta. chains of complement C4b-binding protein are closely linked in a head-to-tail arrangement
Journal Article
·
Tue Jan 10 23:00:00 EST 1995
· Immunogenetics
·
OSTI ID:75610
Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus
Journal Article
·
Fri May 01 00:00:00 EDT 1992
· Molecular and Cellular Biology; (United States)
·
OSTI ID:7160193
Human genes for the. alpha. and. beta. chains of complement C4b-binding protein are closely linked in a head-to-tail arrangement
Journal Article
·
Fri Jun 01 00:00:00 EDT 1990
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:6213675