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Title: Abnormal scintigraphic evolution in AA hepatic amyloidosis

Abstract

A patient with AA amyloidosis secondary to ankylosing spondylitis showed intense liver uptake of Tc-99m MDP on bone imaging. The biopsy showed hepatic amyloid deposition. A repeat bone scan with Tc-99m MDP 1 year later was negative, although the clinical signs and liver function tests of the patient had not changed. A mechanism might exist, other than the affinity of amyloid to calcium, which would explain the extraosseous uptake of pyrophosphates and diphosphonates in organs and soft tissues affected by systemic amyloidosis.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Nuclear Medicine Service, Barcelona (Spain)
OSTI Identifier:
6954174
Resource Type:
Journal Article
Resource Relation:
Journal Name: Clin. Nucl. Med.; (United States); Journal Volume: 13:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; METABOLIC DISEASES; DIAGNOSIS; SKELETON; SCINTISCANNING; ERRORS; ISOMERIC NUCLEI; LIVER; PATIENTS; PYROPHOSPHATES; SPONDYLITIS; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RHEUMATIC DISEASES; SKELETAL DISEASES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Lomena, F., Rosello, R., Pons, F., Grau, M., Garcia, A., Catafau, A., and Setoain, J. Abnormal scintigraphic evolution in AA hepatic amyloidosis. United States: N. p., 1988. Web. doi:10.1097/00003072-198803000-00015.
Lomena, F., Rosello, R., Pons, F., Grau, M., Garcia, A., Catafau, A., & Setoain, J. Abnormal scintigraphic evolution in AA hepatic amyloidosis. United States. doi:10.1097/00003072-198803000-00015.
Lomena, F., Rosello, R., Pons, F., Grau, M., Garcia, A., Catafau, A., and Setoain, J. Tue . "Abnormal scintigraphic evolution in AA hepatic amyloidosis". United States. doi:10.1097/00003072-198803000-00015.
@article{osti_6954174,
title = {Abnormal scintigraphic evolution in AA hepatic amyloidosis},
author = {Lomena, F. and Rosello, R. and Pons, F. and Grau, M. and Garcia, A. and Catafau, A. and Setoain, J.},
abstractNote = {A patient with AA amyloidosis secondary to ankylosing spondylitis showed intense liver uptake of Tc-99m MDP on bone imaging. The biopsy showed hepatic amyloid deposition. A repeat bone scan with Tc-99m MDP 1 year later was negative, although the clinical signs and liver function tests of the patient had not changed. A mechanism might exist, other than the affinity of amyloid to calcium, which would explain the extraosseous uptake of pyrophosphates and diphosphonates in organs and soft tissues affected by systemic amyloidosis.},
doi = {10.1097/00003072-198803000-00015},
journal = {Clin. Nucl. Med.; (United States)},
number = ,
volume = 13:3,
place = {United States},
year = {Tue Mar 01 00:00:00 EST 1988},
month = {Tue Mar 01 00:00:00 EST 1988}
}