Chemical Computer Man: Chemical Agent Response Simulation (CARS). Technical report, January 1983-September 1985

Technical Report · Tue Mar 01 00:00:00 EST 1988

OSTI ID:6953333

Davis, E G; Mioduszewski, R J

The Chemical Computer Man: Chemical Agent Response Simulation (CARS) is a computer model and simulation program for estimating the dynamic changes in human physiological dysfunction resulting from exposures to chemical-threat nerve agents. The newly developed CARS methodology simulates agent exposure effects on the following five indices of human physiological function: mental, vision, cardio-respiratory, visceral, and limbs. Mathematical models and the application of basic pharmacokinetic principles were incorporated into the simulation so that for each chemical exposure, the relationship between exposure dosage, absorbed dosage (agent blood plasma concentration), and level of physiological response are computed as a function of time. CARS, as a simulation tool, is designed for the users with little or no computer-related experience. The model combines maximum flexibility with a comprehensive user-friendly interactive menu-driven system. Users define an exposure problem and obtain immediate results displayed in tabular, graphical, and image formats. CARS has broad scientific and engineering applications, not only in technology for the soldier in the area of Chemical Defense, but also in minimizing animal testing in biomedical and toxicological research and the development of a modeling system for human exposure to hazardous-waste chemicals.

• Research Organization: Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD (USA)
• OSTI ID: 6953333
• Report Number(s): AD-A-193850/5/XAB; CRDEC-TR-88067
• Country of Publication: United States
• Language: English

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