Rodent carcinogens: Setting priorities

Journal Article · Fri Oct 09 04:00:00 EDT 1992 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.1411524· OSTI ID:6952195

Gold, L S; Slone, T H; Stern, B R; Manley, N B; Ames, B N ^[1]

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1. Lawrence Berkeley lab., CA (United States)

The human diet contains an enormous background of natural chemicals, such as plant pesticides and the products of cooking, that have not been a focus of carcinogenicity testing. A broadened perspective that includes these natural chemicals is necessary. A comparison of possible hazards for 80 daily exposures to rodent carcinogens from a variety of sources is presented, using an index (HERP) that relates human exposure to carcinogenic potency in rodents. A similar ordering would be expected with the use of standard risk assessment methodology for the same human exposure values. Results indicate that, when viewed against the large background of naturally occurring carcinogens in typical portions of common foods, the residues of synthetic pesticides or environmental pollutants rank low. A similar result is obtained in a separate comparison of 32 average daily exposures to natural pesticides and synthetic pesticides residues in the diet. Although the findings do not indicate that these natural dietary carcinogens are important in human cancer, they cast doubt on the relative importance for human cancer of low-dose exposures to synthetic chemicals.

• DOE Contract Number: AC03-76SF00098
• OSTI ID: 6952195
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 258:5080; ISSN SCIEA; ISSN 0036-8075
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MODELS
CARCINOGENESIS
DIET
MAMMALS
PATHOGENESIS
PESTICIDES
RISK ASSESSMENT
RODENTS
VERTEBRATES
XENOBIOTICS