Recurrent 1; 17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity

Journal Article · Mon Aug 01 04:00:00 EDT 1994 · American Journal of Human Genetics; (United States)

OSTI ID:6949911

Caron, H; Sluis, P van; Westerveld, A; Slater, R; Versteeg, R; Kraker, J de; Voute, P A ^[1]; Roy, N van; Speleman, F

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1. Univ. of Amsterdam (Netherlands)

Neuroblastomas often show loss of heterozygosity of the chromosomal region 1p36 (LOH 1p), probably reflecting loss of a tumor-suppressor gene. Here the authors describe three neuroblastoma tumors and two cell lines in which LOH 1p results from an unbalanced translocation between the p arm of chromosome 1 and the q arm of chromosome 17. Southern blot and cytogenetic analyses show that in all cases the chromosome 17 homologue from which the 1;17 translocation was derived is still present and intact. This suggests a model in which a translocation between the short arm of chromosome 1 and the long arm of chromosome 17 takes place in the S/G2 phase of the cell cycle and results in LOH 1p. Nonhomologous mitotic recombination in the S/G2 phase is a novel mechanism of LOH. 24 refs., 5 figs., 1 tab.

• OSTI ID: 6949911
• Journal Information: American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 55:2; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
BODY
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DISEASES
HUMAN CHROMOSOME 1
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
MUTATIONS
NEOPLASMS
NERVE TISSUE
TISSUES