Comparative cytotoxicity of chlorophenols to cultured fish cells

Journal Article · Sat Oct 01 00:00:00 EDT 1994 · Environmental Toxicology and Chemistry; (United States)

DOI:https://doi.org/10.1002/etc.5620131014· OSTI ID:6945670

Saito, Hotaka; Shigeoka, Tadayoshi ^[1]

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1. Mitsubishi-kasi Inst. of Toxicological and Environmental Sciences, Yokohama (Japan)

In vitro cytotoxicity of chlorophenols to Cyprinus carpio brain (CCB) cells derived from carp and Oryzias latipes fin (OLF-136) cells derived from medaka was examined with the neutral red (3-amino-7-dimethylamino-2-methylphenazine hydrochloride) incorporation assay. Results were compared with previous cytotoxicity data of chlorophenols to goldfish (Carassius auratus) scale (GFS) cells derived from the goldfish. There were excellent correlations between the 24-h NR50 values of chlorophenols toward the three kinds of cells (r[sup 2] > 0.94).

• OSTI ID: 6945670
• Journal Information: Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 13:10; ISSN ETOCDK; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOASSAY
BIOLOGICAL VARIABILITY
CELL CULTURES
CHLORINATED AROMATIC HYDROCARBONS
FISHES
GENETIC VARIABILITY
HALOGENATED AROMATIC HYDROCARBONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
SENSITIVITY
TOXICITY
VERTEBRATES