beta. -Adrenergic stimulation of brown adipocyte proliferation

Journal Article · Fri Jan 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6945415

Geloeen, A; Collet, A J; Guay, G; Bukowiecki, L J ^[1]

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1. Laval Univ., Quebec City (Canada) Laboratoire de Thermoregulation et Metabolisme Energetique, Lyon (France)

The mechanisms of brown adipose tissue (BAT) growth were studied by quantitative photonic radioautography using tritiated thymidine to follow mitotic activity. To identify the nature of the adrenergic pathways mediating brown adipocyte proliferation and differentiation, the effects of cold exposure (4 days at 4{degree}C) on BAT growth were compared with those induced by treating rats at 25{degree}C with norepinephrine (a mixed agonist), isoproterenol (a {beta}-agonist), and phenylephrine (an {alpha}-agonist). Norepinephrine mimicked the effects of cold exposure, not only on the mitotic activity, but also on the distribution of the labeling among the various cellular types. Isoproterenol entirely reproduced the effects of norepinephrine both on the labeling index and on the cellular type labeling frequency. These results demonstrate that norepinephrine triggers a coordinated proliferation of brown adipocytes and endothelial cells in warm-exposed rats that is similar to that observed after cold exposure. They also suggest that cold exposure stimulates BAT growth by increasing the release of norepinephrine from sympathetic nerves and that the neurohormone activates mitoses in BAT precursor cells via {beta}-adrenergic pathways.

• OSTI ID: 6945415
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:1; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ADRENAL HORMONES
ADRENALINE
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
AZINES
BIOLOGICAL EFFECTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL DIFFERENTIATION
CELL DIVISION
CELL PROLIFERATION
CONNECTIVE TISSUE
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
MAMMALS
MITOSIS
NEUROREGULATORS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHYSIOLOGY
PYRIMIDINES
RATS
RIBOSIDES
RODENTS
SYMPATHOMIMETICS
TEMPERATURE EFFECTS
THYMIDINE
TISSUES
TRITIUM COMPOUNDS
VERTEBRATES