The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: An animal model

Journal Article · Sun Apr 01 00:00:00 EST 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90408-C· OSTI ID:6945287

Konski, A; Weiss, C; Rosier, R; Poulter, C; Pelligrini, V; Anthony, P; Evarts, C M; Richardson, M; Henzler, M; Rubin, P ^[1]

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1. Strong Memorial Hospital, Rochester, NY (USA)

Radiation has been shown to be effective in the prevention of heterotopic bone. The exact etiology of heterotopic bone is unknown. Total hip prosthetic devices that do not depend upon bone cement for fixation have become increasingly popular. The mechanism by which the bone forms around the prosthesis is similar to the process by which fractures heal which has been shown to be sensitive to irradiation. Using a rabbit model we have undertaken a study to investigate the effect of irradiation on the bony ingrowth on porous coated implants. Forty-five rabbits had porous coated implants surgically placed in the tibiae bilaterally. Each rabbit had one tibia randomly irradiated with 1,000 cGy in 5 fractions starting on the first post-operative day. Animals were sacrificed weekly starting 2 weeks post-operatively and the tibae were sent for pullout studies. The amount of force necessary to pullout the treated tibae was statistically less than the amount of force necessary to remove the untreated tibae at 2 weeks. From 3 weeks on there was no difference in the force necessary to remove the prosthesis from the untreated or treated tibae. Histologically, the untreated tibae showed bone formation while the treated tibae did not. Because of these results, it is suggested that the treatment of patients at risk for development of heterotopic bone be modified to only include the area between the femur and pelvis avoiding treatment of the prosthetic device.

• OSTI ID: 6945287
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 18:4; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
TIBIA
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL MODELS
FRACTIONATED IRRADIATION
HEALING
NEOPLASMS
PROSTHESES
RABBITS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
DISEASES
IRRADIATION
MAMMALS
MEDICAL SUPPLIES
ORGANS
RADIATION EFFECTS
RECOVERY
SKELETON
VERTEBRATES
560152* - Radiation Effects on Animals- Animals