Mouse endogenous retroviral long terminal repeat (LTR) elements and environmental carcinogenesis
Conference
·
OSTI ID:6941967
For the past several years, the working hypothesis of this laboratory has been that chromosomal retrovirus-related gene elements play important roles in gene-rearrangement and gene-activation events of carcinogenesis and mutagenesis induced by environmental agents. This working hypothesis is based on the concept of transposable genes as well as the recent understanding of retroviruses (RNA tumor viruses) in relation to the carcinogenesis problem. Activation of transposable gene elements has been discussed from the viewpoint of unprogrammed genomic changes in response to unanticipated genomic shocks. This view was used in considering the possibility of transposable gene elements involved in genetic changes of cancer formation in the animal. In this regard, this concept is similar to the perspectives of RNA tumor viruses, the oncogene-virogene hypothesis, and the provirus hypothesis because retroviruses replicate through DNA forms that carry long terminal repeat (LTR) sequences resembling the insertion sequences (or the IS elements) of prokaryotic transposons. The finding of oncogene myc activation in avian leukosis virus-induced leukemogenesis and proviral insertion in the mouse dilute locus mutation have also pointed to the functional similarity between retroviruses and transposable genes.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6941967
- Report Number(s):
- CONF-880423-1; ON: DE88015569
- Country of Publication:
- United States
- Language:
- English
Similar Records
Variation of LTR size in molecular clones of the BALB/c endogenous ecotropic molecular leukemia virus
Transcriptional promoter and enhancer elements in the long terminal repeats (LTR) of endogenous murine leukemia virus (MuLV)-related proviral sequences
Direct repeats located within a large family of human endogenous retroviral LTRs have transcriptional suppressor activity in human cells
Conference
·
Thu Dec 31 23:00:00 EST 1981
·
OSTI ID:5175479
Transcriptional promoter and enhancer elements in the long terminal repeats (LTR) of endogenous murine leukemia virus (MuLV)-related proviral sequences
Conference
·
Fri May 01 00:00:00 EDT 1987
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:6025570
Direct repeats located within a large family of human endogenous retroviral LTRs have transcriptional suppressor activity in human cells
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· American Journal of Human Genetics
·
OSTI ID:133854
Related Subjects
550200* -- Biochemistry
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
CARCINOGENESIS
CELL TRANSFORMATIONS
CHROMOSOMES
ENVIRONMENTAL EFFECTS
ENVIRONMENTAL EXPOSURE
EVALUATION
FORECASTING
GENES
GROWTH FACTORS
MICROORGANISMS
MITOGENS
ONCOGENIC TRANSFORMATIONS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PATHOGENESIS
PROTEINS
SYNTHESIS
VIRUSES
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
CARCINOGENESIS
CELL TRANSFORMATIONS
CHROMOSOMES
ENVIRONMENTAL EFFECTS
ENVIRONMENTAL EXPOSURE
EVALUATION
FORECASTING
GENES
GROWTH FACTORS
MICROORGANISMS
MITOGENS
ONCOGENIC TRANSFORMATIONS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PATHOGENESIS
PROTEINS
SYNTHESIS
VIRUSES