Multiple myeloma among atomic bomb survivors in Hiroshima and Nagasaki, 1950-76: relationship to radiation dose absorbed by marrow

Journal Article · Sun Aug 01 04:00:00 EDT 1982 · JNCI, J. Natl. Cancer Inst.; (United States)

OSTI ID:6941802

Ichimaru, M; Ishimaru, T; Mikami, M; Matsunaga, M

The relationship between atomic bomb exposure and the incidence of multiple myeloma has been examined in a fixed cohort of atomic bomb survivors and controls in the life-span study sample for Hiroshima and Nagasaki. From October 1950 to December 1976, 29 cases of multiple myeloma were confirmed in this sample. Our analysis shows that the standardized relative risk (RR) adjusted for city, sex, and age at the time of bombings (ATB) increased with marrow-absorbed radiation dose. The increased RR does not appear to differ between cities or sexes and is demonstrable only for those survivors whose age ATB was between 20 and 59 years. The estimated risk in these individuals is approximately 0.48 cases/million person-years/rad for bone marrow total dose. This excess risk did not become apparent in individuals receiving 50 rad or more in marrow total dose until 20 years or more after exposure.

• Research Organization: Department of Hematology, Nagasaki University School of Medicine, Japan
• OSTI ID: 6941802
• Journal Information: JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 69:2; ISSN JJIND
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
ANIMAL TISSUES
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
DELAYED RADIATION EFFECTS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HIROSHIMA
HUMAN POPULATIONS
JAPAN
LEUKEMIA
MYELOID LEUKEMIA
NAGASAKI
NEOPLASMS
ORGANS
PATHOLOGY
POPULATIONS
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIOINDUCTION
TISSUES