Cold spring harbor symposia on quantitative biology

Conference · Fri Jan 01 04:00:00 EST 1988

OSTI ID:6939794

For many decades, it has been clear that cells have a multitude of ways of sensing their environment and converting a plethora of external signals into measured intracellular responses. Now we realize that many first messengers do not act directly through second messengers, but instead work at the genetic level by binding to cytoplasmically located receptors, which can then bind to DNA and turn on or off the functioning of specific genes. Today, we refer to the way that external signals are passed through various cellular components as signal transduction processes, with receptors and their associated molecules known as biological transducers. Because most transducer molecules are present in very limited amounts, their study at the biochemical level until recently was at best difficult, and hypotheses as to how they functioned were almost impossible to test rigorously. Today, recombinant DNA techniques have dramatically changed the picture. Even very rare receptors are now open to analysis if their respective genes can be cloned, and virtually every month the amino acid sequence of a new key biological transducer is established. The time was thus appropriate last June to hold a Cold Spring Harbor Symposium on the Molecular Biology of Signal Transduction. The final program consisted of 119 speakers, who spoke before an audience of 439, the largest ever yet to attend a Cold Spring Harbor Symposium. This volume contains 54 papers. Individual papers are indexed separately on the energy data base.

• Research Organization: Cold Spring Harbor Lab., NY (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-88ER60666
• OSTI ID: 6939794
• Report Number(s): CONF-8805382-Pt.2; ISBN: 0-87969-056-9
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
ABSTRACTS
AMP
ANIMAL CELLS
BACTERIA
BIOLOGICAL PATHWAYS
CHEMICAL REACTIONS
DNA
DOCUMENT TYPES
EUMYCOTA
FUNGI
GROWTH FACTORS
HORMONES
LEADING ABSTRACT
MEETINGS
MEMBRANE PROTEINS
MICROORGANISMS
MITOGENS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
NUCLEOTIDES
ORGANIC COMPOUNDS
PHOSPHORYLATION
PLANTS
PROTEINS
RECEPTORS
RECOMBINANT DNA
STEROID HORMONES
STEROIDS
YEASTS