Decreased glucose transporter 1 gene expression and glucose uptake in fetal brain exposed to ethanol

Journal Article · Tue Dec 31 23:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90030-S· OSTI ID:6938183

Singh, S P; Pullen, G L; Srivenugopal, K S; Xiaohua, Yuan; Snyder, A K ^[1]

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1. Veterans Affairs Medical Center, North Chicago, IL (United States) Chicago Medical School, North Chicago, IL (United States)

Using pregnant rats fed equicaloric liquid diets (AF, ad libitum-fed controls; PF, pair-fed controls; EF, ethanol-fed), the authors have previously shown that maternal alcoholism produces a specific and significant decrease of glucose in the fetal brain, which is accompanied by growth retardation. To further define the mechanisms of ethanol-induced perturbations in fetal fuel supply, they have examined (I) the uptake of 2-deoxyglucose (2-DG) by dissociated brain cells from fetal rats that were exposed to ethanol in utero and (II) the steady-state levels of the glucose transporter-1 (GT-1) mRNA. A 9% decrease in brain weight and a 54.8% reduction in 2-DG uptake into brain cells were found in offspring of EF mothers compared to the AF group. Brain weight correlated with the rate of 2-DG uptake. Northern blot analysis showed a 50% reduction of GT-1 mRNA in EF brain relative to that in the AF and PF groups. They conclude that glucose transport into the brain is an important parameter altered by maternal ethanol ingestion.

• OSTI ID: 6938183
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 51:7; ISSN 0024-3205; ISSN LIFSAK
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALDEHYDES
ANIMAL GROWTH
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
ETHANOL
FETUSES
GENE REGULATION
GLUCOSE
GROWTH
HEXOSES
HYDROXY COMPOUNDS
INGESTION
INHIBITION
INTAKE
MAMMALS
MEMBRANE TRANSPORT
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PREGNANCY
RATS
RODENTS
SACCHARIDES
TOXICITY
VERTEBRATES