Biochemical effects of three chlorinated phenols in rat liver
The hepatic biochemical effects of four chlorinated oxygen containing environmental contaminants were determined. Two oral doses of 1/5 the LD50 of 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol and 2,3,4,6-tetrachlorophenol were given 21 and 4 hours before sacrifice to adult female rats. Although 2,4,6-trichlorophenol is a carcinogen in lifetime rodent studies, no evidence was found for DNA damage in rat liver or the white cells of rat blood. Similiarly no compound related changes were found in serum alanine aminotransferase, hepatic glutathione or cytochrome P-450 content. A dose of 193 mg/kg/day (slightly over the published rat LD50) of 2,3,4,6-tetrachlorophenol increased 5-fold the activity of hepatic ornithine decarboxylase. As 2,4,6-trichlorophenol did not damage DNA or induce hepatic ornithine decarboxylase (a marker of carcinogenic promotion) in the study, no explanation is apparent why this molecule is a carcinogen in rodent lifetime exposures and structurally related congeners are not.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 6936928
- Report Number(s):
- PB-90-232265/XAB; EPA-600/J-88/522
- Resource Relation:
- Other Information: Pub. in Toxicological and Environmental Chemistry, Vol. 16, 165-172(Feb 1988)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED ALIPHATIC HYDROCARBONS
TOXICITY
ALANINES
AMINOTRANSFERASES
CARCINOGENESIS
DECARBOXYLASES
DNA
DOSE-RESPONSE RELATIONSHIPS
ENZYME INDUCTION
GLUTATHIONE
LEUKOCYTES
LIVER
MIXED-FUNCTION OXIDASES
ORNITHINE
PHENOLS
RATS
TABLES
AMINO ACIDS
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DRUGS
ENZYMES
GENE REGULATION
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROXY COMPOUNDS
LYASES
MAMMALS
MATERIALS
NITROGEN TRANSFERASES
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PATHOGENESIS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSFERASES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology