Acute effects of irradiation on middle ear mucosa

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Ann. Otol., Rhinol., Laryngol.; (United States)

DOI:https://doi.org/10.1177/000348948809700215· OSTI ID:6936726

Ohashi, Y; Nakai, Y; Esaki, Y; Ikeoka, H; Koshimo, H; Onoyama, Y

Single field, fixed irradiation of bilateral tympanic cavities using 200-kV x-rays was administered to five guinea pigs. The irradiation dose was 30 Gy. They were killed immediately after irradiation, and bilateral middle ear mucosa was examined for ciliary activity and epithelial structure. Significant deterioration of the ciliary activity in the middle ear mucosa was observed, proximal as well as distal to the eustachian tube. Electron microscopy showed various changes in the irradiated middle ear mucosa. The most conspicuous findings were hyperreactivity in secretion, vacuolation of ciliated cells, and stomal edema.

• Research Organization: Osaka City Univ. Medical School (Japan)
• OSTI ID: 6936726
• Journal Information: Ann. Otol., Rhinol., Laryngol.; (United States), Journal Name: Ann. Otol., Rhinol., Laryngol.; (United States) Vol. 97; ISSN AORHA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AUDITORY ORGANS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
EPITHELIUM
GUINEA PIGS
IONIZING RADIATIONS
MAMMALS
MEMBRANES
MICROSCOPY
MUCOUS MEMBRANES
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSE ORGANS
TISSUES
VERTEBRATES
X RADIATION