Effect of disodium cromoglycate (DSCG) and antihistamines on postirradiation cerebral blood flow and plasma levels of histamine and neurotensin

Journal Article · Mon Feb 01 00:00:00 EST 1988 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(88)90307-7· OSTI ID:6936715

Cockerham, L G; Pautler, E L; Carraway, R E; Cochrane, D E; Hampton, J D

In an attempt to elucidate mechanisms underlying the irradiation-induced decrease in regional cerebral blood flow (rCBF) in primates, hippocampal and visual cortical blood flows of rhesus monkeys were measured by hydrogen clearance, before and after exposure to 100 Gy, whole-body, gamma irradiation. Systemic blood pressures were monitored simultaneously. Systemic arterial plasma histamine and neurotensin levels were determined preirradiation and postirradiation. Compared to control animals, the irradiated monkeys exhibited an abrupt decline in systemic blood pressure to 23% of the preirradiation level within 10 min postirradiation, falling to 12% by 60 min. A decrease in hippocampal blood flow to 32% of the preirradiation level was noted at 10 min postirradiation, followed by a slight recovery to 43% at 30 min and a decline to 23% by 60 min. The cortical blood flow for the same animals showed a steady decrease to 29% of the preirradiation levels by 60 min postirradiation. Animals given the mast cell stabilizer disodium cromoglycate and the antihistamines mepyramine and cimetidine before irradiation did not exhibit an abrupt decline in blood pressure but displayed a gradual decrease to a level 33% below preirradiation levels by 60 min postirradiation. Also, the treated, irradiated monkeys displayed rCBF values that were not significantly different from the nonirradiated controls. The plasma neurotensin levels in the irradiated animals, treated and untreated, indicated a nonsignificant postirradiation increase above control levels. However, the postirradiation plasma histamine levels in both irradiated groups showed an increase of approximately 1600% above the preirradiation levels and the postirradiation control levels.

• Research Organization: Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
• OSTI ID: 6936715
• Journal Information: Fundam. Appl. Toxicol.; (United States), Vol. 10:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIHISTAMINICS
RADIOSENSITIVITY EFFECTS
BRAIN
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
HISTAMINE
BIOSYNTHESIS
PEPTIDES
BLOOD PRESSURE
GAMMA RADIATION
MONKEYS
WHOLE-BODY IRRADIATION
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SYNTHESIS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals