Modulating effect of cerulein on benzodlazepine receptors
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6936695
This paper studies the role of benzodiazepine receptors in the anticonvulsant action of cerulein. Parallel with the study of the behavioral reactions, the effect of cerulein binding of tritium-flunitrazepam was investtigated in vitro and in vivo. It was shown that preliminary subcutaneous injection of relatively high doses of cerulein (over 100 micro/kg) delayed the development of picrotoxin seizures; the latent period of clonic and tonic convulsions and the survival of the mice were lengthened. In doses inhibiting picrotoxen seizures, cerulein significantly inhibited binding of tritium-flunitrazepam in vitro.
- Research Organization:
- Tartu Univ.
- OSTI ID:
- 6936695
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:12; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTICONVULSANTS
ANTIGENS
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
EPILEPSY
IN VITRO
IN VIVO
INHIBITION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MEMBRANE PROTEINS
MICE
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
PSYCHOTROPIC DRUGS
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTICONVULSANTS
ANTIGENS
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
EPILEPSY
IN VITRO
IN VIVO
INHIBITION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MEMBRANE PROTEINS
MICE
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
PSYCHOTROPIC DRUGS
RADIORECEPTOR ASSAY
RECEPTORS
RODENTS
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES