Radioprotection of rat subependymal plate with 4-OH sodium butyrate

Journal Article · Fri Jan 01 04:00:00 EST 1988 · NCI Monogr.; (United States)

OSTI ID:6936694

Davey, P; Grieve, F; Ranaldi, V A

The central nervous system is a radiation-dose-limiting structure, and cellularity of the rat subependymal plate (a location of neuroglial stem cells) has been used as a model of radiation damage. In the present work, an attempt has been made to improve its radiation tolerance using 4-OH sodium butyrate (gamma OH). Adult rats received 10-Gy 250-kV (peak) x-rays or 3.5-Gy 15-MeV deuterons plus Be neutrons. Cell counts were obtained by histological examination of the subependymal plate. Photon and neutron irradiation alone resulted in a mean cell depletion of 62% and 58%, respectively, compared with sham-irradiated controls, which was not statistically significant; the relative biologic effectiveness was 2.9. In the absence of radiation, gamma OH did not significantly alter the cellularity of the subependymal plate, compared with that in controls treated with chloral hydrate. At doses greater than or equal to 1 g/kg, gamma OH was associated with a statistically significant reduction of subependymal plate cell depletion in animals treated with photon or neutron radiation, and the magnitude of the effect was similar. Arterial blood gas analysis failed to show a significant difference in arterial oxygen tension between control and test animals.

• Research Organization: Univ. of Edinburgh (Scotland)
• OSTI ID: 6936694
• Journal Information: NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 6; ISSN NCIME
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BODY
BRAIN
BUTYRIC ACID
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
HADRONS
IONIZING RADIATIONS
MAMMALS
MASSLESS PARTICLES
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
NEUTRONS
NONMETALS
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN
PHOTONS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RBE
RODENTS
VERTEBRATES
X RADIATION