Pyridostigmine interaction with soman during chronic exposure in rodents. Interim report, February-November 1987
The effects of repeated low-level nerve agent exposure on animal performance and lethality are a major concern of USAF Medical Research. This concern has generated interest in the role that pretreatment drugs such as pyridostigmine may play during simultaneous exposure to soman. This role was investigated by recording lethality, weights, symptoms, and cholinesterase (ChE) inhibition in rats chronically exposed to 4 levels of soman (32, 39, 48 or 59 micrograms/kg/day) while simultaneously receiving 10.0 milligrams/kg/day pyridostigmine, 1.0 milligrams/kg/day pyridostigmine, or vehicle via an osmotic pump. No effect (either protective or detractive) was found in the soman-poisoned animals due to the presence or absence of pyridostigmine. However, rat blood biochemistry is different from that of the primate, warranting further study in the primate before extrapolation to man.
- Research Organization:
- School of Aerospace Medicine, Brooks AFB, TX (USA)
- OSTI ID:
- 6936382
- Report Number(s):
- AD-A-192138/6/XAB; USAFSAM-TR-87-38
- Country of Publication:
- United States
- Language:
- English
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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLESTERASES
CHEMICAL WARFARE AGENTS
CHEMISTRY
CHOLINESTERASE
CHRONIC EXPOSURE
DIFFUSION
DOCUMENT TYPES
DRUGS
ENZYMES
ESTERASES
EXTRAPOLATION
HYDROLASES
INHIBITION
LABORATORY ANIMALS
MAMMALS
MATERIALS
NUMERICAL SOLUTION
OSMOSIS
PROGRESS REPORT
PUMPS
RATS
RODENTS
TOXICITY
VERTEBRATES
WEAPONS