Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(88)90131-2· OSTI ID:6936126

Di Renzo, G; Amoroso, S; Taglialatela, M; Canzoniero, L M.T.; Maida, P; Lombardi, G; Annuziato, L

The effects of diclofensine, a pure dopamine (DA) uptake inhibitor on 1) /sup 3/H-DA uptake in rat arcuate-periventricular nucleus-median eminence synaptosomes, 2) basal and K+-evoked endogenous DA release from tuberoinfundibular dopaminergic (TIDA) neurons and 3) in vivo prolactin (PRL) secretion were studied. Diclofensine, in concentrations of 0.01, 0.1 and 1 ..mu..M caused a marked decrease of /sup 3/H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration. On the other hand, diclofensine caused a 3 fold enhancement on K+-evoked DA release. Finally, the compound, when administered in vivo to male rats, significantly reduced basal serum PRL levels. The results of the present study seem to indicate that the pharmacological blockade of DA uptake in TIDA neurons is a condition sufficient to cause a reduction of PRL release.

• Research Organization: Univ. of Naples (Italy)
• OSTI ID: 6936126
• Journal Information: Life Sci.; (United States), Vol. 42:21
• Country of Publication: United States
• Language: English

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SYMPATHOLYTICS
BIOLOGICAL EFFECTS
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TRACER TECHNIQUES
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NEUROREGULATORS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
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