Sister chromatid exchange analysis in lung and peripheral blood lymphocytes of mice exposed to methyl isocyanate by inhalation
Journal Article
·
· Environ. Mutagen.; (United States)
Mice were exposed to 1, 3, or 6 ppm methyl isocyanate (MIC) for 6 hr/day for four consecutive days. Lung cells and peripheral blood lymphocytes (PBLs) were removed and cultured for analysis of sister chromatid exchange (SCE) and cell cycle kinetics. MIC caused a small but significant increase in SCE frequency of cultured lung cells from mice exposed to 1, 3, or 6 ppm MIC. MIC did not significantly increase SCE levels in PBLs of mice exposed to concentrations as high as 6 ppm. In cultured PBLs, MIC had a stimulatory effect on cell cycling rates as measured by the replicative index, and it caused a significant reduction in mononuclear leucocyte counts and the mitotic indices.
- Research Organization:
- Environmental Health Research and Testing, Inc., Research Triangle Park, NC
- OSTI ID:
- 6934723
- Journal Information:
- Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 9:1; ISSN ENMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
IN VITRO
INHALATION
INTAKE
ISOCYANATES
KINETICS
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MITOTIC INDEX
MUTATIONS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
IN VITRO
INHALATION
INTAKE
ISOCYANATES
KINETICS
LEUKOCYTES
LUNGS
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MITOTIC INDEX
MUTATIONS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES