Bioconcentration potential of organic environmental chemicals in humans
A list of environmental chemicals detectable in adipose tissue and/or milk of non-occupationally exposed humans is presented. Besides their physiochemical properties (n-octanol/water partition coefficient and water solubility), their acceptable daily intake (ADI) values, production figures, fate in the environment, concentrations in human adipose tissue, and data from total diet studies from market basket investigations are given. Average bioconcentration factors (BCF) of polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), DDT, hexachlorobenzene (HCB), dieldrin, hexachlorocyclohexane isomers (alpha-HCH, beta-HCH, gamma-HCH, delta-HCH), pentachlorophenol (PCP), and 3,5-di-tert-butyl-4-hydroxytoluene (BHT) in human adipose tissue are calculated. The bioconcentration factors (wet wt basis) of these compounds are between 3 and 47 times higher in humans than in rats. The environmental chemicals are divided into three groups in respect to their bioconcentration factors in human adipose tissue: group I, high BCF (greater than 100); group II, medium BCF (10-100); and group III, low BCF (less than 10). The bioconcentration factors are useful for hazard assessment of chemicals to humans.
- Research Organization:
- Gesellschaft fuer Strahlen und Umweltforschung mbH Muenchen, Germany, F.R.
- OSTI ID:
- 6934673
- Journal Information:
- Regul. Toxicol. Pharmacol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL ACCUMULATION
DDT
DIELDRIN
DIOXIN
TOLUENE
ADIPOSE TISSUE
DIET
LIVER
MAN
MILK
TISSUE DISTRIBUTION
UPTAKE
ALKYLATED AROMATICS
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
FOOD
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INSECTICIDES
MAMMALS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PESTICIDES
PRIMATES
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology