Induction of chromosome aberrations by Fusarium T-2 toxin in cultured human peripheral blood lymphocytes and Chinese hamster fibroblasts
T-2 toxin is an important representative of trichothecenes produced by various species of imperfect fungi, mainly Fusarium genus. No definite data demonstrating the carcinogenic potential of T-2 toxin had been reported up to now. The authors demonstrated that T-2 toxin reproducibly induced chromosomal structural aberrations both in cultured human peripheral blood lymphocytes as well as in V/sub 79/ Chinese hamster fibroblasts. The mean percentage of cells with aberration of human lymphocytes from normal individuals induced by T-2 toxin is 49-fold (9.8%) of the mean percentage of corresponding control cultures without T-2 toxin (0.2%). T-2 toxin induced chromosome type (76%) as well as chromatid type (24%) of aberrations; among them, acentric fragment (46%) was the most common type, and chromatid gap, deletion, and chromosome gap were the next most common. T-2 toxin can induce aberrations in cells at different phases of the cell cycle. There are definite dose-effect relationships within a certain range of dosage of T-2 toxin in experiments with both human peripheral blood lymphocytes and V/sub 79/ cells. T-2 toxin exhibited three types of effects on cells, namely, mitogenic at lowest concentration, clastogenic (chromosome aberration) at median concentration, and cytotoxic at higher concentration. The dose-effect curves of these three effects are partly overlapping. Sex or age effect was not observed. The results suggest that T-2 toxin has carcinogenic potentials. The dosage of aflatoxin that can induce chromosomal aberration of human peripheral blood lymphocytes is thousands-fold of the dosage of T-2 toxin as shown in this report.
- Research Organization:
- Cancer Institute, Beijing, China
- OSTI ID:
- 6934218
- Journal Information:
- J. Cell. Physiol., Suppl.; (United States), Vol. 4; Conference: Proceedings of an international symposium on cancer: perspective for control, Beijing, China, 18-21 Aug 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TOXINS
GENETIC EFFECTS
CELL CULTURES
CELL CYCLE
CHROMOSOMAL ABERRATIONS
FIBROBLASTS
FUSARIUM
HAMSTERS
LYMPHOCYTES
MAN
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
FUNGI
LEUKOCYTES
MAMMALS
MATERIALS
MUTATIONS
PARASITES
PLANTS
PRIMATES
RODENTS
SOMATIC CELLS
TOXIC MATERIALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology