Iodine-131 labeled anti-CEA polyclonal antibody detection of gastrointestinal cancer
To localize gastrointestinal tumor, 31 patients were injected with 1.7-2.1 mCi I-131 anti-CEA baboon polyclonal antibody. Whole body imaging at 48, 72, and occasionally 96 hrs was performed with a Signa Camera (Technicare) peaked at 364 keV with 20% window. Additional spot views were usually obtained. No subtraction methods were used. All patients had surgical and pathological confirmation of the nuclear medicine studies. Labeled antibody images were positive in 15 (8 recurrent or metastatic colorectal, 2 gastric, 1 pancreatic, 1 primary colon, and 1 breast metastatic to chest wall). In 1, antibody images were positive for metastatic deposits in para-aortic lymph nodes, but negative for primary rectal tumor. True negative images were observed in 6; false negative images in 9 (4 liver metastases, 2 rectal, 1 pancreatic, 1 mesenteric lymph node metastasis, 1 bone metastasis). In all cases, no correlation existed between preoperative CEA serum levels and imaging. I-131 labeled anti-CEA polyclonal antibody imaging proved highly efficient in detecting gastric cancer (2/2) and moderately efficient in detecting recurrent colorectal cancer (8/15). On the other hand, the I-131 labeled polyclonal anti-CEA antibody imaging was of limited value in detecting colon cancer (1/9), pancreatic cancer (1/4) and metastatic liver disease (0/4).
- Research Organization:
- The Ohio State Univ.
- OSTI ID:
- 6933080
- Report Number(s):
- CONF-840619-; TRN: 87-008837
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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ANTIBODIES
DIAGNOSTIC USES
LABELLING
GASTROINTESTINAL TRACT
NEOPLASMS
IODINE 131
DIAGNOSIS
APES
CAMERAS
CARCINOEMBRYONIC ANTIGEN
IMAGE PROCESSING
IMAGES
INJECTION
KEV RANGE 100-1000
METASTASES
NUCLEAR MEDICINE
PATHOLOGY
PATIENTS
SURGERY
TRACER TECHNIQUES
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ENERGY RANGE
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KEV RANGE
MAMMALS
MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
PROCESSING
RADIOISOTOPES
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics