skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Quantitative assessment of growth plate activity

Abstract

In the immature skeleton the physis or growth plate is the area of bone least able to withstand external forces and is therefore prone to trauma. Such trauma often leads to premature closure of the plate and results in limb shortening and/or angular deformity (varus or valgus). Active localization of bone seeking tracers in the physis makes bone scintigraphy an excellent method for assessing growth plate physiology. To be most effective, however, physeal activity should be quantified so that serial evaluations are accurate and comparable. The authors have developed a quantitative method for assessing physeal activity and have applied it ot the hip and knee. Using computer acquired pinhole images of the abnormal and contralateral normal joints, ten regions of interest are placed at key locations around each joint and comparative ratios are generated to form a growth plate profile. The ratios compare segmental physeal activity to total growth plate activity on both ipsilateral and contralateral sides and to adjacent bone. In 25 patients, ages 2 to 15 years, with angular deformities of the legs secondary to trauma, Blount's disease, and Perthes disease, this technique is able to differentiate abnormal segmental physeal activity. This is important since plate closure doesmore » not usually occur uniformly across the physis. The technique may permit the use of scintigraphy in the prediction of early closure through the quantitative analysis of serial studies.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Alfred I. DuPont Institute, Wilmington, DE
OSTI Identifier:
6932952
Alternate Identifier(s):
OSTI ID: 6932952
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-008845
Resource Type:
Conference
Resource Relation:
Journal Name: J. Nucl. Med.; (United States); Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BONE JOINTS; INJURIES; SCINTISCANNING; AGE DEPENDENCE; CHILDREN; COMPUTER GRAPHICS; GROWTH; IMAGE PROCESSING; IMAGES; LEGS; PHYSIOLOGY; AGE GROUPS; BODY; BODY AREAS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; LIMBS; ORGANS; PROCESSING; RADIOISOTOPE SCANNING; SKELETON 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Harcke, H.T., Macy, N.J., Mandell, G.A., and MacEwen, G.D.. Quantitative assessment of growth plate activity. United States: N. p., 1984. Web.
Copy to clipboard
Harcke, H.T., Macy, N.J., Mandell, G.A., & MacEwen, G.D.. Quantitative assessment of growth plate activity. United States.
Copy to clipboard
Harcke, H.T., Macy, N.J., Mandell, G.A., and MacEwen, G.D.. Sun . "Quantitative assessment of growth plate activity". United States. doi:.
Copy to clipboard
@article{osti_6932952,
title = {Quantitative assessment of growth plate activity},
author = {Harcke, H.T. and Macy, N.J. and Mandell, G.A. and MacEwen, G.D.},
abstractNote = {In the immature skeleton the physis or growth plate is the area of bone least able to withstand external forces and is therefore prone to trauma. Such trauma often leads to premature closure of the plate and results in limb shortening and/or angular deformity (varus or valgus). Active localization of bone seeking tracers in the physis makes bone scintigraphy an excellent method for assessing growth plate physiology. To be most effective, however, physeal activity should be quantified so that serial evaluations are accurate and comparable. The authors have developed a quantitative method for assessing physeal activity and have applied it ot the hip and knee. Using computer acquired pinhole images of the abnormal and contralateral normal joints, ten regions of interest are placed at key locations around each joint and comparative ratios are generated to form a growth plate profile. The ratios compare segmental physeal activity to total growth plate activity on both ipsilateral and contralateral sides and to adjacent bone. In 25 patients, ages 2 to 15 years, with angular deformities of the legs secondary to trauma, Blount's disease, and Perthes disease, this technique is able to differentiate abnormal segmental physeal activity. This is important since plate closure does not usually occur uniformly across the physis. The technique may permit the use of scintigraphy in the prediction of early closure through the quantitative analysis of serial studies.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}
Copy to clipboard
Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

  • As a result of the nuclear accident at the Chernobyl NPP in 1986, the explosion dispeesed nuclear materials contained in the nuclear fuel of the reactor core over the destroyed facilities at Unit No. 4 and over the territory immediately adjacent to the destroyed unit. The debris was buried under the Cascade Wall. Nuclear materials at the SHELTER can be characterized as spent nuclear fuel, fresh fuel assemblies (including fuel assemblies with damaged geometry and integrity, and individual fuel elements), core fragments of the Chernobyl NPP Unit No. 4, finely-dispersed fuel (powder/dust), uranium and plutonium compounds in water solutions, andmore » lava-like nuclear fuel-containing masses. The new safe confinement (NSC) is a facility designed to enclose the Chernobyl NPP Unit No. 4 destroyed by the accident. Construction of the NSC involves excavating operations, which are continuously monitored including for the level of radiation. The findings of such monitoring at the SHELTER site will allow us to characterize the recovered radioactive waste. When a process material categorized as high activity waste (HAW) is detected the following HLW management operations should be involved: HLW collection; HLW fragmentation (if appropriate); loading HAW into the primary package KT-0.2; loading the primary package filled with HAW into the transportation cask KTZV-0.2; and storing the cask in temporary storage facilities for high-level solid waste. The CDAS system is a system of 3He tubes for neutron coincidence counting, and is designed to measure the percentage ratio of specific nuclear materials in a 200-liter drum containing nuclear material intermixed with a matrix. The CDAS consists of panels with helium counter tubes and a polyethylene moderator. The panels are configured to allow one to position a waste-containing drum and a drum manipulator. The system operates on the ‘add a source’ basis using a small Cf-252 source to identify irregularities in the matrix during an assay. The platform with the source is placed under the measurement chamber. The platform with the source material is moved under the measurement chamber. The design allows one to move the platform with the source in and out, thus moving the drum. The CDAS system and radioactive waste containers have been built. For each drum filled with waste two individual measurements (passive/active) will be made. This paper briefly describes the work carried out to assess qualitatively and quantitatively the nuclear materials contained in high-level waste at the SHELTER facility. These efforts substantially increased nuclear safety and security at the facility.« less

  • ; ; ; ... - J. Nucl. Med.; (United States)
    Indium-111 labeled leukocyte imaging is gaining widespread acceptance. A rapid method for assaying changes in leukocyte viability and phagocytic function during the labeling process would facilitate the evaluation of new labeling techniques and testing of labeled cells before pt injection. The authors have conducted preliminary investigations of chemiluminescence in the clinical evaluation of leukocyte labeling. The chemiluminescence assay may be performed in 30 minutes with only 0.1 ml of whole blood. Zymossan is rapidly introduced to the blood or cell suspension resulting in the emission of light which is then counted by photometer. The amount of light given off bymore » the reaction reflects both the phagocytic function of the cells and the ability of activated phagocytes to generate activated oxygen species. They have evaluated the chemiluminescent activity of normal human leukocyte suspensions both before and after labeling with Indium-111 oxine. The chemiluminescence assay provides a rapid means of evaluating granulocyte function. Correlations of this activity with image quality may provides clues for optimization of labeling techniques.« less

  • ; ; ; ...
    The effect of plate width on the initiation and propagation of fatigue cracks in plate-to-plate T-joints with loading transverse attachment plates and flat fillet-like weld profiles was investigated in a series of constant amplitude fatigue tests. There was no observable effect of plate width on initiation life, propagating life, or total fatigue life, but plate width had a significant effect on crack shape development and crack growth rates. More cracks initiated along the weld toes of wider joints. As a result, the aspect ratios of dominant surface cracks were lower in wider joints, and the dominant surface cracks propagated fastermore » through the thickness of wider base plates. However, there was a greater propensity for edge cracking in narrower specimens because fatigue cracks initiated closer to the free edges of such joints. This offset the faster growth of dominant surface cracks in wider joints so that there was no net effect of plate width on propagation life. A multiple crack linear elastic fracture mechanics model successfully simulated these differences in crack shape development behavior.« less

  • ;
    The two main sources of deposited activities in the Pebble Bed Modular Reactor's (PBMR) Main Power System (MPS), are plate-out of the small fraction of fission product activities released from the PBMR core, and deposition of these activities adsorbed on graphite dust generated during abrasion of the fuel spheres. PBMR uses the German code RADAX for the calculation of fission product transport, plate-out and dust deposition. In this paper a brief overview is given of the plate-out and dust deposition models implemented in the RADAX code. The results of testing activities that were performed for validation of the plate-out modelmore » in the RADAX code are also described. These tests form only part of the overall effort to fully verify and validate RADAX. For validation of the plate-out model, results from past experiments in the out-of-pile loop experiment LAMINAR, as well as the two reactor bypass loop experiments VAMPYR-II of the AVR and the DRAGON Hot Gas Duct, were used as test cases. In this paper, the approach used to set up and execute the test cases is briefly described, examples of the test results are given and discussed, and an evaluation of the ability of the results to validate the RADAX code is provided. (authors)« less

  • ; ; ; ...
    Abstract not provided.