Posttherapeutic change in portal-systemic circulation investigated by T1-201 per-rectal administration

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6929371

Tonami, N; Nakajima, K; Watanabe, N; Yokoyama, K; Seto, M; Seki, H; Koizumi, K; Hisada, K; Kanai, M; Hinoue, Y

A noninvasive method of T1-201 per-rectal administration was performed in patients with esophageal varices to investigate the changes of portal-systemic circulation after treatment. One mCi of T1-201 chloride was given rectally and scintigram and heart/liver uptake ratio at 60 min. after administration (H/L) were investigated before and after sclerosing therapy of esophageal varices by direct injection of ethanolamine oleate under endoscopic guidance (9 patients, 13 cases) and splenic artery emobilization therapy with gelatin sponge block (6 patients). The mean value of H/L was decreased from 1.22 +- 0.21 to 0.96 +- 0.34 in 9 cases who underwent successful varices sclerosing therapy (p<0.05) and marked decrease of H/L and scintigraphic change were observed in 2 cases, but there were 7 cases showing no or a little change, while in 4 cases of unsuccessful sclerosing therapy, H/L was not significantly changed. The mean value of H/L was decreased from 1.15 +- 0.26 to 0.84 +- 0.27 in 6 patients who underwent splenic artery embolization therapy (p<0.005) but there was no significant correlation between H/L change rate and embolization volume of spleen. From these results, the authors understand that portal-systematic shunting greatly depends on esophageal varices in cases showing highly decreased H/L after sclerosing therapy and does not much depend on esophageal varices in cases showing no or a little change in H/L. This method seems to be useful in evaluating pathophysiological changes in portal-systemic shunting by treatments of portal circulation.

• Research Organization: School of Medicine, Kanazawa Univ., Kanazawa
• OSTI ID: 6929371
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ESOPHAGUS
GLANDS
HEART
HEAVY NUCLEI
INJECTION
INTAKE
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGY
PATIENTS
PHYSIOLOGY
PORTAL SYSTEM
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RECTAL ADMINISTRATION
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
THERAPEUTIC USES
THERAPY
TRACER TECHNIQUES
UPTAKE
USES
VEINS