Efficiency of high doses radioiodine for destruction of remaining normal thyroid tissue after total thyroidectomy

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6929334

Schuemichen, C; Blattmann, H; Bulczak-Schmidt, M

Total thyroidectomy is normally the first step in treatment of thyroid cancer with radioiodine. Total surgical excision has the further advantage of removing possible multicentric disease. However, normal functional remnants are often left behind total surgical thyroidectomy, which has to be destroyed by administration of enough I-131. The efficiency of radioiodine therapy for destruction of remaining thyroid tissue was evaluated in 229 patients, which had received high doses of I-131. In general the first dose was 50mCi, all further treatments were done with 100-150mCi. Of all patients 50% received more than 5, 20% more than 10 and 10% more than 14 treatments. The average I-131 dose was 521mCi (19 GBq) after 5 and 1319mCi (49 GBq) after 10 treatments. A maximum dose of 3550mCi (131 GBq) received one patient with 28 treatments. Scintigraphic controls were done between 48 and 72 hrs after administration of radioiodine with both a gamma camera (whole body) and a rectilinear scanner (local). A total destruction of all functional remnants was assumed if two consecutive scans were negative. A nearly linear dose-response curve was obtained after the first 5 treatments or within the first 3 years, the efficiency of further treatments was more and more lessened but still demonstrable. It is concluded that for destruction of remaining normal thyroid tissue after total surgical thyroidectomy not more than 500mCi I-131 within 3 years should be given. All further treatments with high doses of radioiodine are only of diagnostic value for detection of functional metastases with low radioiodine uptake.

• Research Organization: Albert-Ludwigs-Univ., Freiburg i.Br
• OSTI ID: 6929334
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CAMERAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EFFICIENCY
ENDOCRINE GLANDS
GAMMA CAMERAS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE ADMINISTRATION
RADIOTHERAPY
SCINTISCANNING
SURGERY
THERAPEUTIC USES
THERAPY
THYROID
THYROIDECTOMY
UPTAKE
USES