Risk factors for adenocarcinoma of the lung

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Am. J. Epidemiol.; (United States)

OSTI ID:6927303

Brownson, R C; Reif, J S; Keefe, T J; Ferguson, S W; Pritzl, J A

The relation between various risk factors and adenocarcinoma of the lung was evaluated in a case-control study. Subjects were selected from the Colorado Central Cancer Registry from 1979-1982 in the Denver metropolitan area. A total of 102 (50 males and 52 females) adenocarcinoma case interviews and 131 (65 males and 66 females) control interviews were completed. The control group consisted of persons with cancers of the colon and bone marrow. The risk estimates associated with cigarette smoking were significantly elevated among males (odds ratio (OR) = 4.49) and females (OR = 3.95) and were found to increase significantly (p less than 0.01) with increasing levels of cigarette smoking for both males and females. For adenocarcinoma in females, the age- and smoking-adjusted odds ratios at different levels of passive smoke exposure followed an increasing overall trend (p = 0.05). After additional adjustment for potential confounders, prior cigarette use remained the most significant predictor of risk of adenocarcinoma among males and females. Analysis restricted to nonsmoking females revealed a risk of adenocarcinoma of 1.68 (95% confidence interval (Cl) = 0.39-2.97) for passive smoke exposure of four or more hours per day. Neither sex showed significantly elevated risk for occupational exposures, although males bordered on significance (OR = 2.23, 95% Cl = 0.97-5.12). The results suggest the need to develop cell type-specific etiologic hypotheses.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6927303
• Journal Information: Am. J. Epidemiol.; (United States), Journal Name: Am. J. Epidemiol.; (United States) Vol. 1; ISSN AJEPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
BODY
CARCINOGENS
CARCINOMAS
COLLOIDS
DISEASES
DISPERSIONS
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
LUNGS
NEOPLASMS
OCCUPATIONAL EXPOSURE
ORGANS
RESIDUES
RESPIRATORY SYSTEM
RISK ASSESSMENT
SMOKES
SOLS
TOBACCO SMOKES