Statistical evaluation of calibration curve nonlinearity in isotope dilution gas chromatography/mass spectrometry

Journal Article · Fri Dec 31 23:00:00 EST 1982 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00252a042· OSTI ID:6922799

Jonckheere, J A ^[1]; De Leenheer, A P; Steyaert, H L

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1. Farmaceutisch Instituut, Gent, Belgium

Instead of artificially transforming the data to a linear model for the isotope dilution mass spectrometry (IDMS) curve, a polynomial regression was desired to describe the relationship between isotope ratios and mole ratios. The described calculation procedure was tested by applying it to synthetic data generated by the basic IDMS equation and was compared with actual data from an IDMS study of Bromhexine, a mucolytic drug (C/sub 14/H/sub 22/N/sub 2/Br/sub 2/), and its trideuterated analog. The model was found to approximately describe the curvature of the calibration curve.

• OSTI ID: 6922799
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 55:1; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400203* -- Isotope Exchange & Isotope Separation-- (-1987)
400303 -- Organic Chemistry-- Isotope Exchange & Isotope Separation-- (-1987)
CALIBRATION
CHROMATOGRAPHY
FLUIDS
GAS CHROMATOGRAPHY
GASES
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
MASS SPECTROSCOPY
MATHEMATICAL MODELS
SEPARATION PROCESSES
SPECTROSCOPY
STATISTICAL MODELS
TRACER TECHNIQUES