Significant prolongation of segmental pancreatic allograft survival in two species

Journal Article · Wed Jun 01 04:00:00 EDT 1988 · J. Surg. Oncol.; (United States)

DOI:https://doi.org/10.1002/jso.2930380217· OSTI ID:6922561

Du Toit, D F; Heydenrych, J J

A study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL 1 in combination with CSA in baboons. Total pancreatectomy in the dog and primate provided a reliable diabetic model, induced an absolute deficiency of insulin and was uniformly lethal if not treated. Continuous administration of CSA in baboons resulted in modest allograft survival. As in baboons, dogs receiving CSA 25 mg/kg/d rendered moderate graft prolongation but a dose of 40 mg/kg/d resulted in significant graft survival (greater than 100 days) in 5 of 8 allograft recipients. Irradiation alone resulted in minimal baboon pancreatic allograft survival of 20 baboons receiving TL1 1,000 rad and CSA, 3 had graft survival greater than of 100 days. Of 15 baboons receiving TL1 800 rad and CSA, 6 had graft survival of greater than 100 days. In conclusion, CSA administration in dogs and TL1 in combination with CSA in baboons resulted in highly significant segmental pancreatic allograft survival.

• Research Organization: Univ. of Stellenbosch Medical School, Tygerberg (South Africa)
• OSTI ID: 6922561
• Journal Information: J. Surg. Oncol.; (United States), Journal Name: J. Surg. Oncol.; (United States) Vol. 38:2; ISSN JSONA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
APES
BIOLOGICAL FUNCTIONS
BIOLOGICAL MODELS
BODY
BONE MARROW
DIGESTIVE SYSTEM
DOGS
DRUGS
ENDOCRINE GLANDS
FUNCTIONS
GLANDS
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
MAMMALS
ORGANS
PANCREAS
PRIMATES
RADIOSENSITIVITY EFFECTS
SURVIVAL TIME
SYNERGISM
TISSUES
TRANSPLANTS
VERTEBRATES