Review of the literature and a risk assessment
This paper reviews the evidence, primarily epidemiologic, pertaining to the relation between benzene and leukemia. Benzene is widely considered to be a leukemogen for human beings, but its potency is uncertain. Since low-level exposures to benzene characterize many occupational settings, it is important to determine to what extent, if at all, low exposure increase leukemia risk. Moreover, the US Occupational Safety and Health Administration is attempting to reduce workplace exposures from an eight-hour time-weighted average level of 10 parts per million (ppm) to 1 ppm. This paper also includes an evaluation and critique of various risk assessments of benzene and leukemia. These risk assessments were done for policy making and were developed to predict the leukemogenic effect of benzene exposures in the vicinity of the present occupational standard of 10 ppm. 64 references.
- Research Organization:
- Univ. of Alabama, Birmingham (USA)
- OSTI ID:
- 6922071
- Journal Information:
- Am. J. Epidemiol.; (United States), Journal Name: Am. J. Epidemiol.; (United States) Vol. 127:3; ISSN AJEPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AROMATICS
BENZENE
CARCINOGENESIS
DOCUMENT TYPES
EPIDEMIOLOGY
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
LEUKEMOGENESIS
NATIONAL ORGANIZATIONS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PATHOGENESIS
REVIEWS
RISK ASSESSMENT
STANDARDS
US DOL
US ORGANIZATIONS
US OSHA