Thyroid function after mantle irradiation in Hodgkin's disease
The thyroid function of 64 patients with Hodgkin's disease who received mantle irradiation during the period 1966 to 1976 was studied. More than two-thirds (44 to 64) had some thyroid dysfunction. Twenty had mild dysfunction manifested by an abnormal thyroid-stimulating hormone response to thyrotropin-releasing hormone. Twenty had what could be termed compensated hypothyroidism while four were overtly hypothyroid. The severity of dysfunction was not related to age, sex, or chemotherapy. We found, however, that decreased thyroid function was inversely proportional to the length of time between a diagnostic lymphangiogram and the radiation therapy. These results are consistent with the hypothesis that the iodine load of the lymphangiogram renders the thyroid gland more radiosensitive. Thyroxine suppression of the thyroid gland during the period from the lymphangiogram through the termination of radiation therapy is suggested as a means of avoiding thyroid injury.
- Research Organization:
- Dartmouth-Hitchcock Medical Center, Hanover, NH
- OSTI ID:
- 6921632
- Journal Information:
- J. Am. Med. Assoc.; (United States), Vol. 245:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
HODGKINS DISEASE
RADIOTHERAPY
THYROID
CHEMOTHERAPY
HYPOTHYROIDISM
PATIENTS
RADIOSENSITIVITY
THYROXINE
TRH
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOLOGY
THERAPY
THYROID HORMONES
550600* - Medicine
550603 - Medicine- External Radiation in Therapy- (1980-)
550900 - Pathology