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Kinetic model of cadmium metabolism in the human being

Journal Article · · Environ. Res.; (United States)
;
An eight-compartment kinetic model for the metabolism of cadmium was formulated based on animal and human tissue distribution data. The flow of cadmium between the compartments was generally assumed to follow first-order exponential functions. The 21 distribution coefficients were estimated by fitting the calculated cadmium concentrations in kidney, liver, urine, blood, and other tissues to the observed concentrations for Swedes with different smoking habits and with and without occupational cadmium exposure. The calculated tissue concentrations for Japanese persons also agreed with observed concentrations. The model was used to calculate the daily cadmium intake necessary to reach critical concentration in kidney cortex. The average renal cortex concentration would reach 200 ..mu..g/g at an average daily cadmium intake via food of 440 ..mu..g for a European-American population and 325 ..mu..g for a Japanese population.
Research Organization:
The Karolinska Inst., Stockholm
OSTI ID:
6921081
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 16:1-3; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

550500 -- Metabolism
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CADMIUM
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EUROPE
FOOD
GLANDS
INTAKE
KIDNEYS
KINETICS
LIVER
MAMMALS
MAN
MATHEMATICAL MODELS
MATHEMATICS
METABOLISM
METALS
ORGANS
PRIMATES
REACTION KINETICS
SCANDINAVIA
SWEDEN
TISSUE DISTRIBUTION
TISSUES
URINE
VERTEBRATES
WASTES