Exercise-induced silent myocardial ischemia in patients with vasospastic angina

Journal Article · Wed Feb 28 23:00:00 EST 1990 · American Heart Journal; (USA)

DOI:https://doi.org/10.1016/S0002-8703(05)80277-7· OSTI ID:6920966

Aoki, M; Koyanagi, S; Sakai, K; Irie, T; Takeshita, A; Nakamura, M; Nakagaki, O ^[1]

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1. Kyushu Univ., Fukuoka (Japan)

To clarify the incidence and clinical characteristics of exercise-induced myocardial ischemia in patients with vasospastic angina, we performed exercise thallium computed tomography in 25 patients who had no significant coronary artery stenosis greater than 70%. Coronary artery spasm was documented by coronary angiography in all patients. Eleven patients (44%) developed exercise-induced perfusion defects, but only four of them had anginal pain (36%). Diltiazem (90 mg, administered orally) prevented the development of exercise-induced perfusion defects in all patients. Multivessel coronary spasm was documented by coronary angiography in 11 patients, and nine of them (82%) showed exercise-induced perfusion defects (p less than 0.05). From this study it can be concluded: (1) Exercise-induced myocardial ischemia was demonstrated in 44% of patients who had vasospastic angina without fixed coronary stenosis, and 64% of them were asymptomatic. (2) Patients with multivessel spasm had a greater prevalence of exercise-induced myocardial ischemia than those with single-vessel spasm.

• OSTI ID: 6920966
• Journal Information: American Heart Journal; (USA), Journal Name: American Heart Journal; (USA) Vol. 119; ISSN AHJOA; ISSN 0002-8703
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORONARIES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
ELECTROCARDIOGRAMS
EMISSION COMPUTED TOMOGRAPHY
EXERCISE
HEART
ISOTOPES
ORGANS
PATIENTS
THALLIUM ISOTOPES
TOMOGRAPHY