Modulation of hemodynamic and vascular filtration changes in diabetic rats by dietary myo-inositol

Journal Article · Wed Feb 28 23:00:00 EST 1990 · Diabetes; (USA)

DOI:https://doi.org/10.2337/diab.39.3.312· OSTI ID:6920224

Pugliese, G; Tilton, R G; Speedy, A; Santarelli, E; Eades, D M; Province, M A; Kilo, C; Sherman, W R; Williamson, J R ^[1]

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1. Washington Univ. School of Medicine, St. Louis, MO (USA)

To assess the potential of myo-inositol-supplemented diets to prevent diabetes-induced vascular functional changes, we examined the effects of diets supplemented with 0.5, 1, or 2% myo-inositol on blood flow and vascular filtration function in nondiabetic control rats and rats with streptozocin-induced diabetes (STZ-D). After 1 mo of diabetes and dietary myo-inositol supplementation, (1) 131I-labeled bovine serum albumin (BSA) permeation of vessels was assessed in multiple tissues, (2) glomerular filtration rate (GFR) was estimated as renal plasma clearance of 57Co-labeled EDTA, (3) regional blood flows were measured with 15-microns 85Sr-labeled microspheres, and (4) endogenous albumin and IgG urinary excretion rates were quantified by radial immunodiffusion assay. In STZ-D rats, 131I-BSA tissue clearance increased significantly (2- to 4-fold) in the anterior uvea, choroid-sclera, retina, sciatic nerve, aorta, new granulation tissue, diaphragm, and kidney but was unchanged in skin, forelimb muscle, and heart. myo-Inositol-supplemented diets reduced diabetes-induced increases in 131I-BSA clearance (in a dose-dependent manner) in all tissues; however, only in new granulation tissue and diaphragm did the 2% myo-inositol diet completely normalize vascular albumin permeation. Diabetes-induced increases in GFR and in urinary albumin and IgG excretion were also substantially reduced or normalized by dietary myo-inositol supplements. Increased blood flow in anterior uvea, choroid-sclera, kidney, new granulation tissue, and skeletal muscle in STZ-D rats also was substantially reduced or normalized by the 2% myo-inositol diet. myo-Inositol had minimal if any effects on the above parameters in control rats.

• OSTI ID: 6920224
• Journal Information: Diabetes; (USA), Journal Name: Diabetes; (USA) Vol. 39:3; ISSN 0012-1797; ISSN DIAEA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COBALT 57
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIABETES MELLITUS
DIET
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EDTA
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
INOSITOL
INOSITOLS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MAMMALS
METABOLIC DISEASES
MICROSPHERES
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
TRACER TECHNIQUES
VERTEBRATES