Small testicles with impaired production of sperm in adult male survivors of childhood malignancies
Journal Article
·
· Cancer (Philadelphia); (USA)
DOI:https://doi.org/10.1002/1097-0142(19900315)65:6<1303::AID-CNCR2820650608>3.0.CO;2-D·
OSTI ID:6919845
- Univ. of Helsinki (Finland)
Testicular size has been studied in 66 adult men who survived leukemia (n = 14) or cancer (n = 52) in childhood. Mean follow-up time was 14.5 years. The testicular size was measured as the length and breadth in mm; testicular volume index was calculated. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and prolactin were measured. A sperm sample was obtained from 46 men. The patients had smaller testicles than healthy medical students; 51 had small testicles. The size was the smallest in patients who survived leukemia. Multivariate analysis showed that the variables with independent effects on testicular size were cranial and testicular irradiation and therapy with cyclophosphamide. Sperm production was dependent on testicular size. We conclude that determination of serum FSH combined with testicular size may offer a practical approach for predicting the subsequent testicular damage in boys with malignancies.
- OSTI ID:
- 6919845
- Journal Information:
- Cancer (Philadelphia); (USA), Journal Name: Cancer (Philadelphia); (USA) Vol. 65:6; ISSN 0008-543X; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DELAYED RADIATION EFFECTS
DISEASES
FSH
GAMETES
GAMETOGENESIS
GERM CELLS
GONADOTROPINS
GONADS
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
KETONES
LEUKEMIA
LH
LTH
MALE GENITALS
MALES
MATHEMATICS
MEDICINE
MULTIVARIATE ANALYSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SPERMATOGENESIS
SPERMATOZOA
STATISTICS
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
THERAPY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DELAYED RADIATION EFFECTS
DISEASES
FSH
GAMETES
GAMETOGENESIS
GERM CELLS
GONADOTROPINS
GONADS
HEMIC DISEASES
HORMONES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
KETONES
LEUKEMIA
LH
LTH
MALE GENITALS
MALES
MATHEMATICS
MEDICINE
MULTIVARIATE ANALYSIS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SPERMATOGENESIS
SPERMATOZOA
STATISTICS
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
THERAPY