Sympathetic denervation impairs responses of brown adipose tissue to VMH stimulation

Journal Article · Sat Nov 01 04:00:00 EST 1986 · Am. J. Physiol.; (United States)

OSTI ID:6915070

Minokoshi, Y; Saito, M; Shimazu, T

Effects of unilateral surgical denervation of the interscapular brown adipose tissue (IBAT) on its thermogenic and lipogenic responses to electrical stimulation of the ventromedial hypothalamic (VMH) nucleus were studied in anesthetized rats. The rapid rise in IBAT temperature in response to VMH stimulation was greatly suppressed in the denervated IBAT, whereas the temperature response was not impaired in the contralateral innervated IBAT in the same animals. Similarly, the increased rates of conversion of (/sup 14/C) glucose and (/sup 3/H)H/sub 2/O to fatty acids and glyceride glycerol in vivo in IBAT after VMH stimulation were almost completely inhibited by sympathetic denervation. These results indicate clearly that the increases in lipogenic and thermogenic activities in IBAT in response to VMH stimulation are mediated by the sympathetic nerve supply of this tissue.

• Research Organization: Ehime Univ., Shigenobu, Ehime 791-02, Japan
• OSTI ID: 6915070
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States); ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ALDEHYDES
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CONNECTIVE TISSUE
GLUCOSE
HEXOSES
HYPOTHALAMUS
INHIBITION
LABELLED COMPOUNDS
LIPIDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RATS
RODENTS
SACCHARIDES
STIMULATION
TEMPERATURE MEASUREMENT
TISSUES
TRITIUM COMPOUNDS
TRITIUM OXIDES
VERTEBRATES