Selenium-induced enhancement of hematoporphyrin derivative phototoxicity in murine bladder tumor cells
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where selenite alone was non-toxic. Sodium selenite enhanced the fluorescence emission of Hpd and augmented the Hpd-sensitized photooxidation of tryptophan. The data suggest that sodium selenite is able to disaggregate Hpd, thereby enhancing Hpd-sensitized phototoxicity.
- Research Organization:
- Loma Linda Univ., CA
- OSTI ID:
- 6914206
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
ELEMENTS
HEMATOPORPHYRINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOTOSENSITIVITY
PIGMENTS
PORPHYRINS
PYRROLES
RODENTS
SELENIUM
SEMIMETALS
SENSITIVITY
TOXICITY
TRYPTOPHAN
TUMOR CELLS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
ELEMENTS
HEMATOPORPHYRINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOTOSENSITIVITY
PIGMENTS
PORPHYRINS
PYRROLES
RODENTS
SELENIUM
SEMIMETALS
SENSITIVITY
TOXICITY
TRYPTOPHAN
TUMOR CELLS
VERTEBRATES