Synthesis and biological activity of cyclopenta epoxides of PAH (polycyclic aromatic hydrocarbons) containing peripherally fused cyclopenta rings
Polycyclic aromatic hydrocarbons (PAH) containing peripherally fused cyclopenta rings have been identified in soots from many different combustion sources. Metabolism and mutagenicity studies have been reported on the series of four cyclopenta-fused isomers derived from benzanthracene. On the basis of metabolite profiles and S9 concentration dependence of bacterial mutagenicity, it has been suggested that Aroclor 1254-induced rat liver S9 activates benz(e)aceanthrylene, benz(j)aceanthrylene, and benz(l)aceanthrylene predominantly via epoxidation of the cyclopenta ring, while other routes must be involved in the case of benz(k)acephenanthrylene. To test these conclusions, the cyclopenta epoxides of all four isomers of the cyclopenta benzanthracene derivatives were synthesized and their biological activity evaluated in the Ames assay.
- Research Organization:
- North Carolina Univ., Chapel Hill (USA). School of Public Health
- OSTI ID:
- 6908163
- Report Number(s):
- PB-88-218474/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL PATHWAYS
CHEMICAL REACTIONS
COMBUSTION PRODUCTS
CYTOCHROMES
HAZARDOUS MATERIALS
HYDROCARBONS
MAMMALS
MATERIALS
MEETINGS
METABOLISM
MUTAGENS
ORGANIC COMPOUNDS
OXIDATION
PIGMENTS
POLYCYCLIC AROMATIC HYDROCARBONS
PROTEINS
RATS
RODENTS
SOOT
VERTEBRATES