Dynamic cardiac SPECT computer simulations for teboroxime kinetics

Conference · Mon Aug 01 04:00:00 EDT 1994 · IEEE Transactions on Nuclear Science (Institute of Electrical and Electronics Engineers); (United States)

OSTI ID:6906787

Smith, A M; Gullberg, G T ^[1]

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1. Univ. of Utah, Salt Lake City, UT (United States). Dept. of Radiology and Bioengineering

A series of computer simulations was performed to examine the effect that each of seven factors have on the accuracy of the kinetic parameters (k[sub 21] and k[sub 12]) of teboroxime (a [sup 99m]Tc-labeled heart perfusion agent). The parameters k[sub 21] and k[sub 12] can be estimated using dynamic SPECT imaging and tracer kinetic modeling. The factors investigated were: (1) projection/reconstruction process of a time-varying tracer, (2) cardiac motion, (3) temporal resolution of the images, (4) attenuation effects, (5) emission statistics, (6) correlation of estimated parameters, and (7) decreased extraction fraction of teboroxime over time. The results showed that factors (3) and (6) affected only the %RMS error of the estimated parameters k[sub 21] and k[sub 12] and that the smallest error can be obtained by: using 5 second temporal resolution and selecting tissue ROIs which contain the least amount of intraventricular blood. Factors (2), (4), (5), and (7) significantly affected the accuracy of either k[sub 21] or k[sub 12] and efforts should be made in the future to either model or correct for these factors.

• OSTI ID: 6906787
• Report Number(s): CONF-931051--
• Conference Information: Journal Name: IEEE Transactions on Nuclear Science (Institute of Electrical and Electronics Engineers); (United States) Journal Volume: 41:4PT1
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DATA COVARIANCES
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEART
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESOLUTION
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SPATIAL RESOLUTION
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOI