PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23
- Indiana Univ., Indianapolis, IN (United States)
- Univ. of Washington School of Medicine, Seattle, WA (United States)
The v-ets oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, the authors isolated a new member of v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34[sup +]HLA-DR[sup [minus]] hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids. 32 refs., 2 figs.
- OSTI ID:
- 6903299
- Journal Information:
- Genomics; (United States), Vol. 20:2; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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