Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34

Journal Article · Mon Mar 14 23:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1166· OSTI ID:6902929

Hendershot, L M; Valentine, V A; Morris, S T; Shapiro, D N ^[1]; Lee, A S ^[2]

---

1. St. Jude Children's Research Hospital, Memphis, TN (United States)
2. Univ. of Southern California School of Medicine, Los Angeles, CA (United States)

BiP/GRP78 is a member of the HSP70 family involved in the folding and assembly of proteins in the endoplasmic reticulum. Using PCR amplification of DNA from human [times] rodent somatic hybrids that segregate human chromosomes in conjunction with fluorescence in situ hybridization, the authors have assigned GRP78 to chromosome 9q34. This is in agreement with the localization of murine and bovine homologues based on the high degree of synteny in this region. Several interesting genes and disorders map this region and are discussed. 18 refs., 2 figs., 1 tab.

• OSTI ID: 6902929
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 20:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
GENETIC MAPPING
HUMAN CHROMOSOME 9
HUMAN CHROMOSOMES
MAPPING
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
PROTEINS