Sympathetic regulation of cerebral blood flow during seizures in newborn lambs

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:6896316

Kurth, C D; Wagerle, L C; Delivoria-Papadopoulos, M ^[1]

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1. Univ. of Pennsylvania School of Medicine, Philadelphia (USA)

The authors examined cerebral blood flow (CBF) regulation by the sympathetic nerves in 12 newborn lambs during seizures, a potent reflex stimulator of the sympathetic nervous system. CBF was measured with microspheres, and seizures were induced with bicuculline. In six of these lambs, one hemibrain was denervated (D) chronically by interrupting the ipsilateral cervical sympathetic trunk; the other hemibrain remained innervated (I). Before and after 10, 35, and 70 min of seizures, cerebral gray matter blood flow was measured. In the cerebral white matter, hippocampus, caudate, and thalamus blood flows to the D and I hemibrains were similar before seizures but during seizures they were 10-39% greater in the D than in the I hemibrain. Midbrain, brainstem, and cerebellum D and I blood flows were always similar. In the other six lambs, acute denervation during seizures increased ipsilateral cerebral gray and hippocampus blood flow by 10-31%, but unilateral electrical stimulation decreased ipsilateral cerebral gray, cerebral white, hippocampus, thalamus, and caudate blood flow by 17-27%. The data demonstrate that, during seizures, sympathetic nerve activity modifies regional CBF and the effect is sustained, suggesting a role for the sympathetic nervous system in newborn CBF regulation.

• OSTI ID: 6896316
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 255:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH ISOTOPES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
CERIUM 142
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NERVES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOGENESIS
PHYSIOLOGY
RADIOASSAY
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUMINANTS
SCANDIUM 46
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
SHEEP
STABLE ISOTOPES
STRONTIUM 85
STRONTIUM ISOTOPES
TIN 113
TIN ISOTOPES
VERTEBRATES