Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Ann. N.Y. Acad. Sci.; (United States)

DOI:https://doi.org/10.1111/j.1749-6632.1988.tb30116.x· OSTI ID:6895281

Maltoni, C; Lefemine, G; Tovoli, D; Perino, G

Three propellant chlorofluorocarbons, namely trichlorofluoromethane (FC11), dichlorodifluoromethane (FC12), and chlorodifluoromethane (FC22) were administered by inhalation at a concentration of 5000, 1000 and 0 ppm, 4 hours daily, 5 days weekly, for 104 and 78 weeks, to rats and mice, respectively. The animals were kept under observation until spontaneous death. Under the experimental conditions, all three compounds failed to show any carcinogenic effects.

• Research Organization: Institute of Oncology F. Addarii, Bologna (Italy)
• OSTI ID: 6895281
• Journal Information: Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 534; ISSN ANYAA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CARCINOGEN SCREENING
CARCINOGENESIS
DISEASES
FREONS
HALOGENATED ALIPHATIC HYDROCARBONS
INHALATION
INTAKE
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SCREENING
VERTEBRATES